Research

New released videos (scientific publications below)

MLC Tracking with dosimetry

RayPilot® electromagnetic tumor tracking system used for MLC Tracking on a Varian RapidArc®. Here used together with the Scandidos Delta4 dose QA system.
The RayPilot® system is placed directly on the carbon fibre couch top. A robotic phantom is moving a "target" consisting of a RayPilot® implantable transmitter and a Delta4 phantom. The motion is detected by the RayPilot® system and information is sent to the Varian RapidArc® collimator so it follows the target continuously.
The work is led by Associate Professor Per Rugård Poulsen and PhD Student Thomas Ravkilde at the Aarhus University Hospital in Denmark.
The RayPilot® is CE-certified for prostate tracking and gives the position 30 times a second. It also has automatic patient identification.
In-situ dosimetry is work in progress.

This video shows a research set-up.

RayPilot® Dosimetry Demo

This video shows a demo of the Micropos RayPilot® System with integrated dosimetry feature to be released.

In this example a light sensitive dosimeter is used and is included in the positioning device.
The "beam" is in this case the lamp that you see turns on and off and you could also see the motion when we are moving the case where the RayPilot® transmitter is.
The position, dose rate and the accumulated dose is presented in real-time and could also be streamed to other systems in real-time.

This video shows a research set-up.

RayPilot® System Response Video

This video shows the response of the Micropos RayPilot® System.
You can see the transmitter in the middle of the red ball and the receiver is in the sensor plate on the couch. Normally the transmitter is implanted into the prostate for target tracking.
The position is acquired 30 times per second with sub mm accuracy.
All data could be streamed out (including the dose*) to other systems.
* Dosimetry to be released

RayPilot® used for chest/surface tracking

This video shows the Micropos RayPilot® System for surface tracking.
The position is acquired 30 times per second with sub mm accuracy.
All data could be streamed out (including the dose*) to other systems.
* Dosimetry to be released

This video shows a research set-up.

RayPilot® used for MLC tracking at the Aarhus University Hospital

RayPilot® used for MLC tracking at the Aarhus University Hospital, Published as poster and article. Fastest system in the world when published.

Geometric accuracy of dynamic MLC tracking with an implantable wired electromagnetic transponder

This video shows a research set-up.

Posters, Publications, Articles and Presentations

RayPilot – electromagnetic real-time positioning in radiotherapy of prostate cancer – initial clinical results

E Castellanos1, M-H Eriksson1, B Sorcini1, U Green2, B. Sten Nilsson1, B Lennernäs3
1 Karolinska University Hospital, Radiumhemmet, Stockholm, Sweden
2 Uddevalla Hospital, Dept of Med Tech, Uddevalla, Sweden
3 Sahlgrenska University Hospital, University of Gothenburg, Sweden

ESTRO 31, 9-13 May 2012, Barcelona, Spain, EP-1122

Patient evaluation of the RayPilot system during radiation therapy of prostate cancer

Kerstin Lidén, Pia Damsgaard Jensen, Åsa Erstorp, Berit Johansson, Lena Mourou, Beata Psilander, Karolinska University Hospital, Radiumhemmet, Stockholm, Sweden

ESTRO 31, 9-13 May 2012, Barcelona, Spain, EP-1112

Clinical experience of real-time tracking with the RayPilot system in patients with prostate cancer

Ulrika Lindencrona1, Karin Braide2, Hanna Syrén3, Sven Hertzman1, Jon Kindblom2
1Dept. of Therapeutic Radiation Physics, Sahlgrenska University Hospital, Gothenburg, Sweden
2Dept. of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden
3Micropos Medical, Gothenburg, Sweden

ESTRO 31, 9-13 May 2012, Barcelona, Spain, EP-1399

3D dosimetry with gels and optical tomography of dynamic MLC tracking based on an electromagnetic transponder system

P S Skyt1,2,3,4, P R Poulsen2, T S Kinnari3, I Wahlstedt3, T Ravkilde2, P J Keall5, J B B Petersen1, P Balling3 and L P Muren1,2,4
1 Dept of Medical Physics, Aarhus University Hospital, Denmark
2 Dept of Oncology, Aarhus University Hospital, Denmark
3 Dept of Physics and Astronomy, Aarhus University, Denmark
4 Dept of Clinical Medicine, Aarhus University, Denmark

ESTRO 31, 9-13 May 2012, Barcelona, Spain, PO-0883

Time resolved evolvement of target dose distribution during IMAT with and without dynamic MLC tracking

T. Ravkilde1, P.J. Keall2, C. Grau1, M. Høyer1, P.R. Poulsen1
1Aarhus University Hospital, Department of Oncology, Aarhus C, Denmark
2The University of Sydney, Sydney Medical School, Sydney, Australia

 

ESTRO 31, 9-13 May 2012, Barcelona, Spain, PD-0343

Geometric accuracy of dynamic MLC tracking with an implantable wired electromagnetic transponder

THOMAS RAVKILDE1, PAUL J. KEALL2,3, KLAUS HØJBJERRE1, WALTHER FLEDELIUS1, ESBEN WORM1 & PER R. POULSEN1,4
1Department of Oncology, Aarhus University Hospital, Denmark
2Central Clinical School, University of Sydney, Australia
3Department of Radiation Oncology, Stanford University, CA, USA
4Institute of Clinical Medicine, Aarhus University, Denmark
Article

Acta Oncologica, 2011; 50: 944–951

Four and five dimensional radiotherapy with reference to prostate cancer – definitions, state of the art and further directions – an overview

BO LENNERNÄS1, ENRIQUE CASTELLANOS2, STEN NILSSON2 & SEYMOUR LEVITT2
1Department of Oncology, Sahlgrenska Hospital and Academy, University of Gothenburg, Gothenburg, Sweden
2Department of Oncology/Pathology, Karolinska University Hospital and Institutet, Stockholm, Sweden
Article

Acta Oncologica, 2011; 50(Suppl 1): 104–110

Electromagnetic Modeling and Design of Medical Implants and Devices

OSKAR TALCOTH, Chalmers University of Technology, Dept. of Signals and Systems, Gothenburg, Sweden

Licentiate thesis, series R, ISSN 1403-266x, Chalmers University of Technology, Gothenburg, Sweden, 2011

Erste Erfarungen mit dem RayPilot® (Micropos) an der Klinik für Strahlenterapie (Univ. Rostock)

Not reviewed summary of the Rostock University Clinics first experience ot the RayPilot® system
Professor G. Hildebrand et al, Rostock University Clinic

Medizinische Physik 2011 - 3 Ländertagung der ÖGMP, DGMP und SGSMP, Wien 28/9-1/10, 2011

3D Dosimetry with Gels and Optical Tomography of Dynamic MLC Tracking Based on an Electromagnetic Transponder System

P Skyt1, P Poulsen1, T Kinnari2, I Wahlstedt2, T Ravkilde1, P Keall3, J Petersen1, P Balling2, and L Muren1
1Aarhus University Hospital, Aarhus, Denmark
2Aarhus University, Aarhus, Denmark
3University of Sydney, Camperdown, Australia
Abstract and Oral Presentation, SU‐C‐224‐01

2011 Joint AAPM/COMP Meeting, July 31 - August 4, Vancouver, Canada

Geometric accuracy of Dynamic MLC tracking with an implantable wired electromagnetic transponder

T. Ravkilde1, P. J. Keall23, K. Hoejbjerre1, W. Fledelius1, E. Worm1, P. R. Poulsen1
1 AARHUS UNIVERSITY HOSPITAL, Department of Oncology, Aarhus C, Denmark
2 UNIVERSITY OF SYDNEY, Sydney Medical School, Sydney, Australia
3 STANFORD UNIVERSITY, Department of Radiation Oncology, Stanford, USA
Abstract and Oral Presentation, 251, Tuesday May 10, 2011

ESTRO Anniversary Congress, 8 - 12 May 2011
Excel Centre, London, United Kingdom

Electromagnetic positioning, real time positioning and four-dimensional radiotherapy using the Raypilot system. First human experience.

Bo Lennernäs* 1, Enrique Castellanos 2, Sten Nilsson 2
1 Institutionen särskilda specialiteter, Göteborgs Universitet, Göteborg
2 Radiumhemmet, Karolinska Institutet, Stockholm
Poster, RT-Poster-18

The NACP and ACTA Oncologica Symposiums 2011, Uppsala, Sweden

Geometric accuracy of DMLC tracking with an implantable wired electromagnetic transponder.

Thomas Ravkilde1, Paul J Keall23, Klaus Højbjerre1, Walther Fledelius1, Esben Worm1, Per R Poulsen1
1 Department of Oncology, Aarhus University Hospital, Aarhus, Denmark
2 Sydney Medical School, The University of Sydney, Australia
3 Department of Radiation Oncology, Stanford University, Stanford, CA, USA
Abstract and Oral Presentation, RT-19

The NACP and ACTA Oncologica Symposiums 2011, Uppsala, Sweden

Fyrdimensionell radioterapi med elektromagnetisk positionering - en metodbeskrivning och exempel vid lokaliserad prostatacancer

Bo Lennernäs 1, Enrique Castellanos 2, Sten Nilsson 2
1 Institutionen för särskilda specialiteter, Göteborgs Universitet, Göteborg
2 Radiumhemmet, Karolinska Institutet, Stockholm
Poster

Läkarstämman 2010, Annual general meeting of the Swedish Society of Medicine, Gothenburg, Sweden

Evaluation of the localization accuracy and precision of the RayPilot® system compared to Cone-Beam CT

Sundqvist E.a, Robbestad W.a, Borgen L.a, Castro A.a, Halnes E.a, Bergstrand E.S.b, a Oslo University College, b Department of Medical Physics, Division for Cancer Medicine and Radiotherapy, Radiumhospital, Oslo University Hospital, Norway
Poster, 1694

ESTRO 29, 12-16 September 2010, Barcelona, Spain

How accurate could the RayPilot® system detect real time motion of the chest during breast radiotherapy?

Sundqvist E., Tran T., Ormestad U., Linh Y.T., Aakervik E., Oslo University College, Norway
Poster

College Of Radiographers Annual Radiotherapy Weekend 2010, Birmingham, United Kingdom

Evaluation of the localization accuracy and precision of the RayPilot® system compared to Cone-Beam CT

Sundqvist E.a, Robbestad W.a, Borgen L.a, Castro A.a, Halnes E.a, Bergstrand E.S.b, a Oslo University College, b Department of Medical Physics, Division for Cancer Medicine and Radiotherapy, Radiumhospital, Oslo University Hospital, Norway
Poster

College Of Radiographers Annual Radiotherapy Weekend 2010, Birmingham, United Kingdom

A new multi-functional implant for 4DRT, including positioning, dose measurement and patient identification.

B Lennernäs M.D. Ph.D.1,R Iustin MSc.2, J Linder MSc.2, H Syrén MSc.2, K Westerlund MSc.3
1 Sahlgrenska University Hospital, University of Gothenburg, Sweden
2 Micropos Medical AB (publ), Gotenburg, Sweden
3 AB Mimator, Uppsala, Sweden
Poster B-350

ASTRO 51, Chicago

Evaluation of positioning accuracy of the electromagnetic RayPilot® system 
with an in vivo dosimeter.

B Lennernäs M.D. Ph.D.1,R Iustin MSc.2, J Linder MSc.2, H Syrén MSc.2
1 Sahlgrenska University Hospital, University of Gothenburg, Sweden
2 Micropos Medical AB (publ), Gothenburg, Sweden
Poster P400

10th Biennial ESTRO meeting on physics and Radiation Technology for Clinical Radiotherapy, August 30 - September 3, 2009, Maastricht, Netherlands

Experiences from testing a radiotherapy support system with QuickCheck

Aiko Fallas Yamashita1, Andreas Bergqvist2, and Thomas Arts2
1 Simula Research Laboratory, Norway
2 IT University of Gothenburg, Sweden
Abstract and Oral presentation

Second International Conference TAP 2008, 
Prato, Italy, April 2008

High precision transponder localization using a novel electromagnetic positioning system in patients with localized prostate cancer

Jon Kindblom1,*, Ann-Marie Ekelund-Olvenmark1, Hanna Syren2, Roman Iustin2, Karin Braide1, Ingela Frank-Lissbrant1, Bo Lennernäs1
1 Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden
2 Micropos Medical AB, Gothenburg, Sweden
Article

Radiotherapy and Oncology 2009 Mar;90(3):307-11. Epub 2008 Oct 24, "The Green Journal"

Technical description of the next generation electromagnetic position device for 4D radiotherapy.

B. Lennernäs 1, S. Nilsson 2, S. Levitt 2, B. Rosengren 3, J. Linder 3, H. Syrén 3, R. Iustin 3
1 Dept. of Oncology, Gothenburg University
2 Radiumhemmet, Karolinska Institute, Stockholm, Sweden
3 Micropos Medical, Sweden
Poster, P1075

ESTRO27, September 14 – 18, 2008 Gothenburg, Sweden

Stochastic Pattern of Motion In the Prostate

Jon Kindblom M.D. Ph.D.1, Hanna Syrén MSc.2, Roman Iustin MSc.2, Bo Lennernäs M.D. Ph.D.1
1 Dept. of Oncology, Gothenburg University, Sweden
2 Micropos Medical, Sweden
Poster, P1077

ESTRO27, September 14 – 18, 2008 Gothenburg, Sweden

Target localization using a novel electromagnetic high precision positioning system in patients with localized prostate cancer

Jon Kindblom M.D. Ph.D.1, Ann-Marie Ekelund-Olvenmark M.D.1, Hanna Syrén MSc.2, Roman Iustin MSc.2, Bo Lennernäs M.D. Ph.D.1
1 Dept. of Oncology, Gothenburg University, Sweden
2 Micropos Medical, Sweden
Poster, P399
9th Biennial ESTRO meeting on physics and Radiation Technology for Clinical Radiotherapy

September 8-13, 2007 Barcelona, Spain

A new implant for automatic high precision real time patient positioning in radiotherapy (RT): a technical description of a GPS system for RT and on its initial test on a phantom and in man

B. Lennernäs1, R. Iustin2, P. Albertsson1, T. Gustafsson2, S.Nilsson3, S. Lewitt3, B. Rosengren2
1Sahlgrenska University Hospital, Univ. of Gothenburg Department of Oncology, Gothenburgs Sweden
2Micropos Medical AB, Chalmers Innovation, Chalmers Univ. of Technology, Gothenburg, Sweden
3University of Stockholm, Radiumhemmet, Stockholm, Sweden
Abstract and Oral Presentation, Wednesday September 28, 2005 ,Proffered Papers Novel technologies, 233

8th Biennial ESTRO meeting on physics and Radiation Technology for Clinical Radiotherapy, 2005, Lisbon, Portugal

 

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ESTRO 2010
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Radiotherapy Weekend 2010		 Läkarstämman 2010

Läkarstämman
2010
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Poster Brochure 2011

Sweden has a long tradition in research and development of radiotherapy and radiotherapy related industry. The founders of Micropos Medical are closely related to this history. For example; Professor emeritus Bengt Rosengren made pioneer work with treatment simulation and portal vision in the beginning of the 1960:s.

Professor Sten Nilsson and associated professor Bo Lennernäs have played a major role in the implementation of high precision radiotherapy, using 3D dose planning and high dose brachytherapy, of prostate cancer in Sweden.

Professor Seymour Levitt is a well-known radiotherapist and editor of the book “Technological Basis of Radiation Therapy”.

Several of the techniques used today in radiotherapy (such as 3D dose planning) were outlined in collaboration between the Nordic countries during the 1980:s. This collaboration was called the CART project and involved the STU (Styrelsen för Teknisk Utveckling, today Nutek, The Swedish Business Development Agency).

During the last decade the CART-group has developed and evaluated different techniques for high precision positioning in real time for external beam radiotherapy. Already in 1995, Dr Bo Lennernäs, applied for a patent for use of electromagnetic fields for patient- and organ- positioning during radiotherapy. In collaboration with Chalmers University of Technology / Chalmers Innovation the R&D of “The tumor positioning group” has been transferred into Micropos Medical AB.

The goal is to improve external beam radiotherapy using high precision techniques with automatic set-ups and positioning detection throughout the whole radiotherapy chain. This includes the first diagnostic investigation (such as MR, PET, CT), through treatment planning and during every second of the treatment. All with the same technique - and with millimetre resolution.

This will fulfill the requirements in 4D radiotherapy.

 magneticimplant_1995_bo

Dr Bo Lennernäs first test in 1995 with magnetic implants for automatic tumor and patient positioning.